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簡(jiǎn)要描述:Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.Involvement in disease: Defects in FGG are a cause of thrombophilia.Defects in FGG are a cause of congenital afibrinogenemia (CAFBN). It is a rare autosomal recessive disorder characterized by complete absence of detectable fibrinogen.
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