當(dāng)前位置:首頁(yè) > 產(chǎn)品中心 > 抗體/抗原 > 標(biāo)記一抗 > bs-0566R-PEPE標(biāo)記的Smad7抗體
簡(jiǎn)要描述:The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this
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